MovDisordV3, Main, Exploration, bibRecord, 001190

Brain Biochemistry in Autopsied Patients with Essential Tremor

Identifieur interne : 001190 ( Main/Exploration ); précédent : 001189; suivant : 001191

Brain Biochemistry in Autopsied Patients with Essential Tremor

Auteurs : Holly A. Shill [États-Unis] ; Charles H. Adler [États-Unis] ; Thomas G. Beach [États-Unis] ; Lih-Fen Lue [États-Unis] ; John N. Caviness [États-Unis] ; Marwan N. Sabbagh [États-Unis] ; Lucia I. Sue [États-Unis] ; Douglas G. Walker [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0106496

Descripteurs français

Pascal (Inist)
- Tremblement, Pathologie du système nerveux, Encéphale, Biochimie, Homme, Anatomopathologie, GABA, Noradrénaline.
Wicri :
- topic : Biochimie, Homme.

English descriptors

KwdEn :
- Anatomic pathology, Biochemistry, Encephalon, GABA, Human, Nervous system diseases, Norepinephrine, Tremor.

Abstract

The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition. We studied several candidate biochemical/anatomical systems in the brain stem, striatum, and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them with a control population. Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ± 113.2 versus 96.4 ± 102.7 ng/mg (not significant) in cases and controls, respectively. Locus coeruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between the essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3 ± 42.0 versus 251.4 ± 74.8 ng/mg (P = .025) in the pons in the region of the locus coeruleus of essential tremor subjects versus controls, whereas there was no difference in cerebellar parvalbumin. These results are supportive of a possible role for reduced GABAergic function in the locus coeruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The pathology of essential tremor is increasingly being studied; however, there are limited studies of biochemical changes in this condition. We studied several candidate biochemical/anatomical systems in the brain stem, striatum, and cerebellum of 23 essential tremor subjects who came to autopsy, comparing them with a control population. Striatal tyrosine hydroxylase, a marker of dopaminergic neurons, was 91.7 ± 113.2 versus 96.4 ± 102.7 ng/mg (not significant) in cases and controls, respectively. Locus coeruleus dopamine beta-hydroxylase, a marker of noradrenergic neurons, was not significantly different between the essential tremor and control groups. Parvalbumin, a marker of GABAergic neurons, was 199.3 ± 42.0 versus 251.4 ± 74.8 ng/mg (P = .025) in the pons in the region of the locus coeruleus of essential tremor subjects versus controls, whereas there was no difference in cerebellar parvalbumin. These results are supportive of a possible role for reduced GABAergic function in the locus coeruleus in essential tremor. The hypothesis that essential tremor represents early Parkinson's disease was not supported, as striatal dopaminergic markers were not reduced compared with control subjects.</div>
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<name sortKey="Caviness, John N" sort="Caviness, John N" uniqKey="Caviness J" first="John N." last="Caviness">John N. Caviness</name>
<name sortKey="Lue, Lih Fen" sort="Lue, Lih Fen" uniqKey="Lue L" first="Lih-Fen" last="Lue">Lih-Fen Lue</name>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Brain Biochemistry in Autopsied Patients with Essential Tremor

Brain Biochemistry in Autopsied Patients with Essential Tremor

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri